Investigating DNA supercoiling in eukaryotic genomes
نویسندگان
چکیده
منابع مشابه
Investigating DNA supercoiling in eukaryotic genomes
Supercoiling is a fundamental property of DNA, generated by polymerases and other DNA-binding proteins as a consequence of separating/bending the DNA double helix. DNA supercoiling plays a key role in gene expression and genome organization, but has proved difficult to study in eukaryotes because of the large, complex and chromatinized genomes. Key approaches to study DNA supercoiling in eukary...
متن کاملSymbiotic DNA in eukaryotic genomes.
The recent explosive growth of molecular genetic databases has yielded increasingly detailed insights into the evolutionary dynamics of eukaryotic genomes. DNA sequences with the self-encoded ability to transpose and replicate are unexpectedly abundant and widespread in eukaryotic genomes. They seem to be sexual parasites. By dispersing themselves among the chromosomes, they increase their tran...
متن کاملConservation and periodicity of DNA bend sites in eukaryotic genomes.
DNA bend sites appear every 680 bp on average in the human epsilon- and beta-globin gene regions. Although most of their molecular nature has not been unraveled, a potential bend core sequence A2N8A2N8A2 (A/A/A) and its complementary T2N8T2N8T2 (T/T/T) appeared preferentially either in or very close to most of the bend sites, whereas other combinations of A2 and T2 dinucleotides, A/T/T + A/A/T,...
متن کاملEvolutionary diversification of DNA methyltransferases in eukaryotic genomes.
In eukaryotes, C5-cytosine methylation is a common mechanism associated with a variety of functions such as gene regulation or control of genomic stability. Different subfamilies of eukaryotic methyltransferases (MTases) have been identified, mainly in metazoa, plants, and fungi. In this paper, we used hidden Markov models to detect MTases in completed or almost completed eukaryotic genomes, in...
متن کاملFunctional Mechanisms of Microsatellite DNA in Eukaryotic Genomes
Microsatellite repeat DNA is best known for its length mutability, which is implicated in several neurological diseases and cancers, and often exploited as a genetic marker. Less well-known is the body of work exploring the widespread and surprisingly diverse functional roles of microsatellites. Recently, emerging evidence includes the finding that normal microsatellite polymorphism contributes...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Briefings in Functional Genomics
سال: 2017
ISSN: 2041-2649,2041-2657
DOI: 10.1093/bfgp/elx007